Tomaschitz A, Pilz S, Ritz E, Grammer T, Drechsler C, Boehm BO, März W
Among 3,153 LURIC patients free of primary kidney disease, plasma aldosterone predicted cardiovascular mortality (HR 1.08 per 50 pg/mL, p = 0.001) and sudden cardiac death (HR 1.11, p < 0.001) over 7.75 years. Stratification by estimated glomerular filtration rate (eGFR) confined this association to the lowest eGFR tertile (HR 1.10; interaction p = 0.001), with no effect at higher eGFR, suggesting impaired renal function amplifies the cardiovascular risk of elevated aldosterone.
American Journal of Kidney Diseases, 24. Dezember 2010 | PMID 21186074