Grammer TB, Kleber ME, Silbernagel G, Pilz S, Scharnagl H, Lerchbaum E, Tomaschitz A, Koenig W et al.
Serum copper and ceruloplasmin concentrations were examined in relation to coronary artery disease and all-cause and cardiovascular mortality in 3,253 LURIC participants. Age- and sex-adjusted hazard ratios for all-cause death, highest versus lowest quartile, were 2.23 for copper and 2.63 for ceruloplasmin; cardiovascular mortality hazard ratios were 2.58 and 3.02, respectively. After further risk-factor adjustment, both associations remained significant, indicating that elevated copper and ceruloplasmin independently predict long-term mortality.
Free Radical Research, 3. April 2014 | PMID 24605902