Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study)

Ruef J, März W, Winkelmann BR

Markers of endothelial dysfunction and oxidative stress were examined in 208 LURIC patients grouped as controls, stable angina, or acute coronary syndromes. Thrombomodulin, von Willebrand factor, sVCAM-1, CRP, SOD, and myeloperoxidase increased with CAD severity, while nitric oxide and sL-selectin were inversely correlated (p < 0.05); most oxidative stress markers showed no consistent trend. Endothelial dysfunction markers thus appear more reliable indicators of CAD presence and severity.

Scandinavian Cardiovascular Journal, Oktober 2006 | PMID 17012137