Lüblinghoff N, Winkler K, Winkelmann BR, Seelhorst U, Wellnitz B, Boehm BO, März W, Hoffmann MM
Two HMOX1 promoter variants – a (GT)n dinucleotide repeat and a -413A>T SNP previously linked to coronary artery disease (CAD) – were examined in 3,219 LURIC participants (2,526 with CAD, 693 controls). Neither variant was associated with biochemical parameters, CAD, or prior myocardial infarction. These results argue against a relevant role for HMOX1 promoter polymorphisms in CAD susceptibility.
BMC Medical Genetics, 23. April 2009 | PMID 19389234