Ivandic BT, Spanuth E, Kleber M, Grammer TB, März W
In a nested case-control analysis of 256 LURIC patients with stable coronary artery disease (128 cardiovascular deaths, 128 matched survivors; 7.5-year follow-up), high-sensitivity troponin T (hsTnT) and NT-proBNP independently predicted cardiovascular mortality (AUCs 0.728 and 0.751). Patients positive for both markers had 60% 5-year cardiovascular mortality versus 10% in marker-negative patients. Adding hsTnT to NT-proBNP significantly improved c-statistics and net reclassification, supporting combined use for risk stratification in stable CAD.
Clinical Chemistry and Laboratory Medicine, 17. Mai 2011 | PMID 21574877