Zewinger S, Speer T, Kleber ME, Scharnagl H, Woitas R, Lepper PM, Pfahler K, Seiler S et al.
In 3,307 LURIC patients followed for a median of 9.9 years, higher HDL cholesterol was associated with lower all-cause (HR 0.51, p = 0.03) and cardiovascular mortality (HR 0.30, p = 0.01) only in patients with normal eGFR; no protective association was observed with reduced kidney function. Confirmed in an independent CKD cohort, the findings suggest that abnormal HDL function may limit the benefit of HDL-targeted therapies in kidney disease.
Journal of the American Society of Nephrology, 7. März 2014 | PMID 24610925