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LURIC

Publikation · PMID 27975104

Prognostic significance of tPA/PAI-1 complex in patients with heart failure and preserved ejection fraction

Winter MP, Kleber ME, Koller L, Sulzgruber P, Scharnagl H, Delgado G, Goliasch G, März W et al.

Among 370 HFpEF patients in LURIC followed for 9.7 years, tPA/PAI-1 complex predicted all-cause mortality (HR 1.24 per 1 SD, 95% CI 1.04-1.47) and cardiovascular mortality (HR 1.26, 95% CI 1.02-1.56) independently of cardiovascular risk factors and NT-proBNP. It also provided incremental prognostic value above NT-proBNP (IDI 0.0157, p = 0.017), suggesting that tPA/PAI-1 complex may usefully complement traditional heart failure biomarkers in clinical HFpEF risk assessment.

Thrombosis and Haemostasis, 15. Dezember 2016 | PMID 27975104

Zeitschrift
Thrombosis and Haemostasis
DOI
10.1160/TH16-08-0600
PMID
27975104
Quelle
https://pubmed.ncbi.nlm.nih.gov/27975104/