Silbernagel G, Scharnagl H, Kleber ME, Stojakovic T, März W
Among 2,139 LURIC participants followed for a median 10.1 years, statin use was associated with higher circulating PCSK9 (244 vs 197 ng/ml, p < 0.001). The highest versus lowest PCSK9 tertile was not associated with all-cause or cardiovascular mortality in the full cohort (HR = 1.09), though a modest association with all-cause mortality emerged in statin-naive individuals (HR = 1.34, p = 0.029). Circulating PCSK9 appears to have limited utility for cardiovascular risk stratification.
European Journal of Preventive Cardiology, 1. Januar 2017 | PMID 28436724