Delgado GE, Zirlik A, Gruber R, Scheffold T, Krämer BK, März W, Kleber ME
The association of INR with mortality was examined in 3064 LURIC participants not on oral anticoagulant therapy. Over a median follow-up of 9.9 years, higher INR was associated with all-cause mortality (HR 1.14, 95% CI 1.07-1.21 per 1-SD increase), but adjustment for NT-proBNP abolished the association, implicating clinical or subclinical heart failure as a key mediating factor.
PloS One, 15. August 2019 | PMID 31415634