Schweighofer N, Genser B, Maerz W, Kleber ME, Trummer O, Pieber TR, Obermayer-Pietsch B
Genotypes of 27 intronic OCT1 SNPs were investigated in the LURIC cohort (n = 3316) for association with all-cause and cardiovascular mortality. Multivariate Cox regression adjusted for cardiovascular risk factors identified 4 SNPs significantly associated with both outcomes in the 73 participants with type 2 diabetes on metformin. The results suggest that OCT1 genotype may stratify cardiovascular mortality risk in metformin-treated patients.
Diabetes, Metabolic Syndrome and Obesity, 18. Juni 2020 | PMID 32606866