Gergei I, Zheng J, Andlauer TFM, Brandenburg V, Mirza-Schreiber N, Müller-Myhsok B, Krämer BK, Richard D et al.
A GWAS meta-analysis of circulating alpha-Klotho levels in 4,376 individuals from LURIC and ALSPAC identified six genome-wide significant signals at five loci (ABO, KL, FGFR1, B4GALNT3, CHST9) explaining more than 9% of trait variance. Mendelian randomization indicated causal effects of Crohn’s disease liability (IVW beta = 0.059) and LDL cholesterol (IVW beta = -0.198) on alpha-Klotho, implicating post-translational modification enzymes and pathways beyond phosphate homeostasis in its regulation.
Human Molecular Genetics, 3. März 2022 | PMID 34542150