The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality

Herrmann M, Keppel MH, Zelzer S, Alonso N, Cavalier E, Kleber M, Enko D, Scharnagl H et al.

Functional vitamin D status, assessed by simultaneous 25(OH)D and 24,25(OH)2D measurement, was examined in 2,456 LURIC participants for associations with coronary atherosclerosis, cardiac biomarkers, and 10-year CVD mortality. CVD mortality was doubled at 25(OH)D below 50 nmol/L (21.6% vs. 11.5%), while functional deficiency yielded rates of 25.0% vs. 16.7%; neither metric predicted coronary obstruction severity. Elevated NT-proBNP and greater heart failure prevalence suggest vitamin D deficiency operates through impaired cardiac function rather than atherosclerosis.

Clinical Chemistry and Laboratory Medicine, 19. Juni 2024 | PMID 38890759