Weyrich M, Zewinger S, Sarakpi T, Rasper T, Kleber ME, Cremer S, Zanders L, Fleck F et al.
Mosaic loss of Y chromosome (LOY) was quantified in 1698 male LURIC participants undergoing coronary angiography and examined in relation to mortality outcomes. LOY exceeding 17% conferred higher all-cause mortality (HR 1.41, 95% CI 1.09-1.82), cardiovascular mortality (HR 1.49, 95% CI 1.09-2.03), and fatal myocardial infarction risk (HR 2.65, 95% CI 1.46-4.81), alongside a profibrotic and proinflammatory plasma protein profile. These findings identify LOY as an independent sex-specific cardiovascular risk factor in men with coronary artery disease.
European Heart Journal, 2. Mai 2025 | PMID 39935193