Förster F, Horn K, Pott J, Delgado GE, Kleber ME, März W, Moissl-Blanke AP, Silbernagel G et al.
A genome-wide association meta-analysis of six cohorts including LURIC (up to 10,519 individuals) examined genetic determinants of cholesterol synthesis intermediates lanosterol, desmosterol, and cholesterol. Four novel genome-wide significant associations were identified, including lanosterol loci at CYP51A1 (7q21.2) and previously reported cholesterol regions HMGCR and APO cluster. Mendelian randomisation analysis suggested that lanosterol’s effect on coronary artery disease is fully mediated by total cholesterol.
EBioMedicine, 30. Januar 2026 | PMID 41619350